Lactated ringer vs normal saline trial#

Lactated ringer vs normal saline trial#

These results underscore the need for a prospective randomized trial comparing pre-hospital LR with NS in patients with TBI. LR was associated with increased mortality compared with NS in patients with TBI. Fluid type had no effect on admission biochemical or physiological parameters, 6-hour RBC, or crystalloid requirement in either group. In patients with TBI ( n = 308), LR was associated with higher adjusted mortality compared with NS (hazard rate = 1.78, confidence interval 1.04–3.04, p = 0.035). Similar to Normal Saline, it distributes. Median ISS, AIS head, AIS extremity, and pre-hospital fluid volume were higher in TBI and non-TBI patients receiving LR compared with NS ( p < 0.01). Hartmanns solution is a balanced isotonic solution containing Na+, Cl, K+, HCO3 (as lactate), Ca2+, and water. Seven hundred ninety-one patients received either LR ( n = 117) or NS ( n = 674). Linear regression models were generated for prediction of red blood cell (RBC) and crystalloid requirement, and admission biochemical/physiological parameters. I have been unable to find any evidence that LR actually causes or exacerbates hyperkalemia. This has led to the common notion that LR should be avoided in a patient with hyperkalemia. Cox proportional hazards models including Injury Severity Score (ISS), AIS head, AIS extremity, age, fluids, intubation status, and hospital site were generated for prediction of mortality. LR has a potassium concentration of 4 mEq/L, whereas the potassium concentration of normal saline (NS) is zero. Patients with TBI (Abbreviated Injury Scale head ≥3) and without TBI (AIS head ≤2) were compared.

We included patients receiving pre-hospital LR or NS from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study.

We sought to determine if pre-hospital LR is associated with improved outcome compared with NS in patients with and without traumatic brain injury (TBI). NS has been associated with increased resuscitation volume, blood loss, acidosis, and coagulopathy compared with LR.

Lactated Ringer's (LR) and normal saline (NS) are both used for resuscitation of injured patients.